Season 4, Episode 11
A haunted house the Winchesters investigate turns out to be not so ghostly in origin at all.
Dean: What kind of ghost messes with a man's wheels?
Dean: It's not a girl. It's psycho Nell.
Brian Carter: After all, what could possibly go wrong in the country?
Dean: Humans, man.
Dean: You know, I felt for those sonsabitches back there. Life long torture turns you into something like that.
Sam: You were in hell, Dean. Look, maybe, you did what you did there but you're not them. They were barely human.
Dean: You're right. I wasn't like them. I was worse. They were animals, Sam, defending territory. Me? I did it for the sheer pleasure.
Sam: What?
Dean: I enjoyed it, Sam. They took me off the rack and I tortured souls and I liked it. All those years, all that pain, finally getting to deal some out yourself. I didn't care who they put in front of me because that...that pain I felt, it just slipped away. No matter how many people I save, I can't change that. I can't fill this hole. Not ever.