Season 6, Episode 5
Sam and Dean encounter vampires on a recruitment drive while investigating the disappearance of 7 teenage girls. Dean is infected with vampire blood and Grandpa Samuel arrives to help with a cure. The question is did Sam actually have Dean's back in the fight?
Sam: Vampires?
Dean: Ah, these aren't vampires, man. These are douche-bags.
Dean: Are you wearing glitter?
Kid: I only wear it to get laid.
Dean: Does it work?
Kid nods.
Dean: I'll be damned.
Sam: Where are you going?
Dean: News flash, Mr. Wizard, vampires pee.
Dean: Oh, God, I'm Pattinson.
Dean: Lisa, I can't bring this crap home to you.
Lisa: You're talking about your work?
Dean: I'm talking about my life. It's ugly, and it's violent, and I'm going to die soon.
Samuel: There's nothing in the recipe about easy.
Vampire: They've reinvented us as Prince Charming with a Volvo.
Supernatural Quotes Season 6